Role of Vascular Risk factors on progression of cognitive impairment in AD

 
   Lead Investigator:    Anand Viswanathan
   Institution      :    Mass ADRC
   E-Mail           :    aviswanathan1@partners.org
   Proposal ID      :    61


   Publications:


1  Viswanathan A, Macklin EA, Betensky R, Hyman B, Smith EE, Blacker D
   The Influence of Vascular Risk Factors and Stroke on Cognition in Late Life: Analysis of the NACC Cohort
   Journal Article  Alzheimer Dis Assoc Disord,29:287-293,2015,PMC4514567

   PUBLISHED





   Proposal Description:
   Role of Vascular Risk factors on progression of cognitive impairment in AD    Hypothesis 1: The presence of vascular risk factors is associated with increased clinical  impairment (executive cognitive dysfunction > memory impairment) in patients with  Alzheimer???s dementia (AD).  Specific Aim 1:We will determine the neurologic consequences of the presence of one or  more or a combination of vascular risk factors in the NACC cohort. We will use  established NACC variables of global cognitive outcome (mini-mental status  examination score, CDR score and CDR sum of boxes), measures of executive function  (Trails B, digit-span), and memory (logical memory test) to assess these differences.  Hypothesis 2: Cognitive impairment progresses more rapidly in individuals with  vascular risk factors compared to those lacking these risk factors.  Specific Aim 2: We will determine the degree of progression of cognitive impairment in  individuals with one or more or a combination of these vascular risk factors. We will  assess changes in variables of global cognitive outcome (mini-mental status examination  score, CDR score and CDR sum of boxes), measures of executive function (Trails B,  digit-span), and memory (logical memory test) at follow-up.